Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist's perspective

0Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Introduction and aim: Adequately preserved slides and tissue blocks in pathology archives, when re-reviewed and associated with patient charts, are important tools to further assess prevalence changes and associations of certain pathologies. Our aim was to identify whether proton-pump inhibitor (PPI) use, dose, and duration of use were associated with gastric polyps and their phenotypes in a case-control study. Methods: The slides from patients with a morphologic diagnosis of either hyperplastic polyps or fundic gland polyps were retrieved from the 1980, 1990, 2000, 2010, and 2016 surgical pathology files at a tertiary care hospital in Mexico City and re-evaluated. Cases were paired by age and sex with patients that underwent endoscopy and gastric mucosa biopsy in the same year, with no evidence of polyps. Results: A total of 133 (3.8%) patients with gastric polyps were identified from 3,499 gastric biopsies taken in the abovementioned years and compared with 133 paired controls. Dyspepsia was more prevalent in the controls (p = 0.002) and abdominal pain was more prevalent in the patients with gastric polyps (p = 0.001). PPI use (OR 7.7, 95% confidence interval, 4.4-13.3) and taking more than one PPI medication (OR 4.9, 95% confidence interval, 1.09-22.3) were significantly associated with the presence of gastric polyps. The fundic gland phenotype in the oxyntic mucosa was more frequently associated with PPI use (p < 0.042), with a continuous increase in its prevalence starting in the year 2000 (p = 0.017 for trend). Conclusion: PPI administration for at least one year was associated with gastric fundic gland polyps.

Cite

CITATION STYLE

APA

Velazquez-Dohorn, M., López-Durand, C. F., Candanedo-González, F., Araujo-Villalvazo, E. A., & Gamboa-Domínguez, A. (2020). Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist’s perspective. Revista de Gastroenterologia de Mexico, 85(1), 42–47. https://doi.org/10.1016/j.rgmx.2019.02.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free