Synthesis and characterization of bis-3,5-disubstituted thiadiazine-2-thione derivatives as anticancer agents

Abstract

Selective cytotoxic effect toward tumor cells but not the normal tissues represent a major challenge in cancer drug discovery. Herein, we describe the synthesis and selective antitumor activity of some HHT. All the synthesized compounds showed a good antitumor activity against leukemia K562 cells. In regard to cytotoxicity in normal cells, compounds (1-11) showed no cytotoxic effect within 200 μM range, however compounds 12-16 showed non-selective cytotoxic effect.