Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

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Abstract

Dooley et al. used parallel analysis of a murine pancreatic cancer model and a human prospective cohort to study the interaction of diet and pancreatic cancer. Both systems identify complex effects with different dietary components, converging on a link between dietary sugar and the cell-cycle checkpoint gene MAD2L1.

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Dooley, J., Lagou, V., Goveia, J., Ulrich, A., Rohlenova, K., Heirman, N., … Liston, A. (2020). Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility. Cell Reports, 32(2). https://doi.org/10.1016/j.celrep.2020.107880

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