Genetics of scleroderma: Implications for personalized medicine?

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Abstract

Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis. © 2013 Assassi et al; licensee BioMed Central Ltd.

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Assassi, S., Radstake, T. R. D. J., Mayes, M. D., & Martin, J. (2013, January 11). Genetics of scleroderma: Implications for personalized medicine? BMC Medicine. https://doi.org/10.1186/1741-7015-11-9

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