Overexpression of Bcl-2 suppresses the calcium activation of a mitochondrial megachannel

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Abstract

The molecular mechanism(s) by which Bcl-2 regulates apoptosis is poorly understood. Bcl-2 suppresses apoptosis by inhibiting calcium activation of the permeability transition of mitochondria. In this patch-clamp study, overexpression of Bcl-2 in mitochondria of cultured cells suppressed calcium activation of a high conductance channel that may underlie the permeability transition. All other single channel parameters were identical when multiple conductance channel activities of mitochondria from control and Bcl-2 overexpressing cells were compared. Bcl-2 forms channels in artificial membranes; however, no novel channel activities could be linked to Bcl-2 overexpression, suggesting Bcl-2 does not form channels in native inner membranes of mitochondria. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Murphy, R. C., Schneider, E., & Kinnally, K. W. (2001). Overexpression of Bcl-2 suppresses the calcium activation of a mitochondrial megachannel. FEBS Letters, 497(2–3), 73–76. https://doi.org/10.1016/S0014-5793(01)02440-1

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