Evolution of erectile dysfunction in individuals infected with human T-lymphotropic virus 1: a prospective cohort study

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Abstract

Background: Virtually all patients with human T-lymphotropic virus 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) have some degree of erectile dysfunction (ED), but ED is also found in a large percentage of HTLV-1 carriers. Aim: To evaluate the evolution of ED in individuals infected with HTLV-1 who were followed for up to 15 years. Methods: This prospective cohort study included men infected with HTLV-1 who had ED, were aged 18 to 70 years, and were followed from January 2004 to December 2019. We used the International Index of Erectile Function–5 (IIEF-5), the Expanded Disability Status Scale and Osame Motor Disability Scale, and the Overactive Bladder Symptom Score (OABSS) to define and stratify ED, neurologic disability, and bladder dysfunction, respectively. Outcomes: Time to development of severe ED was the main outcome. Results: We studied 90 men with ED (mean ± SD age, 52.8 ± 9.78 years). At baseline, 42 were carriers, 16 had probable HAM/TSP, and 32 had definite HAM/TSP. IIEF-5 was highest among carriers and lowest in patients with definite HAM/TSP, whereas OABSS was lowest in carriers and highest in patients with definite HAM/TSP. Median (IQR) follow-up was 8.50 years (3.00-12.00). IIEF-5 fell significantly from baseline to last follow-up among carriers and patients with probable and definite HAM/TSP. There was an inverse correlation between the IIEF-5 and the OABSS at last follow-up (r = −0.62, P

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de Oliveira, C. J. V., Neto, J. A. C., Liberato de Matos, S. N. F., Oliveira, P., Tannus, M., Castro, N., … Carvalho, E. M. (2023). Evolution of erectile dysfunction in individuals infected with human T-lymphotropic virus 1: a prospective cohort study. Journal of Sexual Medicine, 20(3), 269–276. https://doi.org/10.1093/jsxmed/qdac050

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