Role of probiotics on Helicobacter pylori infections

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Helicobacter pylori is the main causal agent of several gastrointestinal disturbances (e.g. chronic gastritis, peptic ulcer, gastric cancer). Treatments based on a combination of antibiotics and proton pump inhibitors are currently used to eradicate the gastric infection. Despite the high eradication rate reached by standard therapies (>80%), because of the high incidence of H. pylori-related diseases worldwide new options to improve the eradication rate are needed. Probiotics are defined as live, non-pathogenic microbial feed or food supplements that exert a positive influence on the host by altering the host's microbial balance. Probiotics seem to exert a direct antimicrobial effect, as shown by in vitro studies, through competition with H. pylori, inhibition of adherence and production of metabolites and antimicrobial molecules. Implementation of probiotics with standard anti-H. pylori regimens can also improve patients' compliance with therapy, reducing the incidence of side-effects associated with antibiotic treatment. This article summarizes the relevant currently available data on the potential benefits of the use of probiotics in the management of H. pylori infection.




Cazzato, I. A., Candelli, M., Nista, E. C., Gasbarrini, G., & Gasbarrini, A. (2004). Role of probiotics on Helicobacter pylori infections. In Scandinavian Journal of Nutrition/Naringsforskning (Vol. 48, pp. 26–31).

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