Riboflavina: uma vitamina multifuncional

Abstract

Recebido em 17/8/04; aceito em 5/11/04; publicado na web em 13/4/05 RIBOFLAVIN: A MULTIFUNCTIONAL VITAMIN. Riboflavin, a component of the B 2 vitaminic complex, plays important roles in biochemistry, especially in redox reactions, due to the ability to participate in both one-and two-electron transfers as well as acting as a photosensitizer. Accordingly, low intakes of this vitamin have been associated with different diseases, including cancer and cardiovascular diseases. Riboflavin is thought to contribute to oxidative stress through its capacity to produce superoxide but, interestingly, it can also promote the reduction of hydroperoxides. This peculiar and multifunctional behavior allows riboflavin to take part in various biochemical pathways as a nucleophile and an electrophile, turning it into a versatile and important biological compound.