Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.
Bevilacqua, P. C. (2002). Battle for the bulge: Directing small molecules to DNA and RNA defects. Chemistry and Biology. Elsevier Ltd. https://doi.org/10.1016/S1074-5521(02)00197-7