Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2

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Abstract

This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)2Cl2, and [Pt(dach)Cl2] on the activity of porcine pancreatic phospholipase A2 (PLA2). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl2] with PLA2 could not be detected under our experimental conditions. © 2013 Informa UK, Ltd.

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Radisavljević, M., Kamčeva, T., Bugarčić, Ž. D., & Petković, M. (2013). Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(4), 651–660. https://doi.org/10.3109/14756366.2012.666539

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