Antioxidant and alleviatory effects of hydroalcholic extract of cauliflower leaves against sodium fluoride-induced cardiotoxicity in Wistar male rats

Abstract

The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.