Metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 are increased in vulvar lichen sclerosus

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Objectives: To evaluate the expression of different matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in vulvar lichen sclerosus (LS), a chronic dermatosis in women, histologically characterized by a zone of collagen remodeling in the superior dermis. Study design: Analysis of the expression of different MMPs (MMP-1, -2, -9 and -13) and TIMPs (TIMP-1 and -2) by reverse transcriptase-polymerase chain reaction (RT-PCR) in vulvar biopsies from patients with LS (n = 11), classified according to Hewitt histological criteria and compared with clinically normal vulvar tissue (n = 5), and the immunohistochemistry of MMP-2 and -9 and TIMP-1 and -2 distribution in the remodeling zone of LS (n = 31) and in clinically normal vulvar tissue (n = 28). Results: Although no statistically significant difference between LS and normal skin groups at the mRNA level of MMP and TIMP transcripts was shown, an increase in the immunodistribution of MMP-2 and -9 and TIMP-1 and -2 in LS compared to normal vulvar skin was observed. Conclusions: These results suggest that these molecules could be related to the process of cutaneous collagen remodeling in LS pathology. © 2011 Elsevier Ireland Ltd.




De Oliveira, G. A. P., De Almeida, M. P., Soares, F. A., De Almeida Filho, G. L., Takiya, C. M., Otazu, I. B., & Nasciutti, L. E. (2012). Metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 are increased in vulvar lichen sclerosus. European Journal of Obstetrics and Gynecology and Reproductive Biology, 161(1), 96–101.

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