Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors

Abstract

Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymicderived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers. © 2013 Landes Bioscience.