Spectrophotometric Methods for Estimation of Diclofenac Sodium in Tablets

Abstract

A simple, rapid, accurate, economical and reproducible spectrophotometric method for estimation of diclofenac sodium (DIC) has been developed. The method employs estimation by straight line equation obtained from calibration curve of diclofenac sodium. The method obeys Beer’s law between 4.64 – 27.84 µg/ml in 20% v/v aqueous methanol as solvent. Results of analysis were validated statistically by ICH guidelines 1996. Keywords:Spectrophotometer, Diclofenac, Validation and Accuracy