Pooled analysis of T2 Candida for rapid diagnosis of candidiasis

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Abstract

Background: The present meta-analysis examined the diagnostic accuracy of T2 Candida for candidiasis. Methods: The literature databases, such as PubMed, Embase, DVIO, Cochrane library, Web of Science, and CNKI, were searched on T2 Candida detection. Results: A total of 8 articles, comprising of 2717 research subjects, were included in the study. The pooled sensitivity and specificity were 0.91 (95% confidence interval (CI): 0.88-0.94) and 0.94 95% CI: 0.93-0.95), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 10.16 (95% CI: 2.75-37.50) and 0.08 (95% CI: 0.02-0.35), respectively. The combined diagnostic odds ratio is 133.65 95% CI: 17.21-1037.73), and the AUC of SROC is 0.9702 [(SE = 0.0235), Q= 0.9201(SE = 0.0381)]. Conclusions: The current evidence supported that T2 Candida has high accuracy and sensitivity and is of major clinical significance in the diagnosis of Candida infection.

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Tang, D. L., Chen, X., Zhu, C. G., Li, Z. W., Xia, Y., & Guo, X. G. (2019). Pooled analysis of T2 Candida for rapid diagnosis of candidiasis. BMC Infectious Diseases, 19(1). https://doi.org/10.1186/s12879-019-4419-z

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