P1112COMPARISON OF EFFICACY BETWEEN MAINTENANCE HEMODIALYSIS AND THEIR COMBINATION WITH HEMOPERFUSION IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS TREATMENT

Abstract

Background and Aims: The occurrence of mid‐and long‐term uremic complications is related to the low clearance rate of middle and large molecule uremic toxins when haemodialysis (HD) alone is adopted. The objective of this study is to evaluate the efficacy of the combination of maintenance HD with hemoperfusion (HP‐HA130) therapy. Method: A total of 36 patients who underwent routine HD were randomly divided into three groups: Group 1 (n=17): received HD + HP (HA130), (HD 3times/W +HP biweekly). Group (n=10): given HD with high flux dialyzer 3 times a week. Group (n=9): given HD with low flux dialyzer 3 times a week. Before and after the observational period blood samples were taken for haemoglobin (Hb), iron (Fe), total iron binding capacity (TIBC), albumin (Alb), calcium (Ca), phosphorus (PO4) and parathyroid hormone (PTH). Results: Patients in group 1 had significantly higher values of TIBC (p<0.05) and significant lower levels of PO4 (p<0.01), there was no significant differences of EPO doses and albumin levels between the 3 groups after the follow up period. In the group 1, serum PO4 levels were significantly lower (p<0.05) and TIBC was significantly higher (p<0.05) after the 4 months of the follow up period than it was at the beginning. In group 2 the values of TIBC were significantly lower after the follow up period than it was at the beginning (p<0.05). No statistical difference between groups after the follow up period was observed in terms of Hb, Fe, PTH, Ca, BMI, duration of dialysis treatment and vascular access. Conclusion: This combination treatment of HD with HP HA130 was superior to HD in reducing levels of phosphorus. These findings suggest a potential role of reducing the risk of cardiovascular events in this population. Also, patients who underwent the combined treatment showed higher values of TIBC, these results eventually demonstrate their role in the improvement of renal disease anaemia, however researches on a larger sample size are needed.