Reduced tissue oxygenation stabilizes the alpha-subunit of the transcription factor hypoxia-inducible factor-1 (HIF-1). This leads to the induction of a number of hypoxia responsive genes. One of the best known HIF-1 targets is erythropoietin that exerts neuroprotective effects on ischemia-related injury in the brain. Thus, pre-exposure to low environmental oxygen concentrations might be exploited as a preconditioning procedure to protect tissues against a variety of harmful conditions. We present recent work on neuroprotection of retinal photoreceptors induced by hypoxic preconditioning or by systemically elevated levels of Epo in mouse plasma. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Grimm, C., Wenzel, A., Acar, N., Keller, S., Seeliger, M., & Gassmann, M. (2006). Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration. In Advances in Experimental Medicine and Biology (Vol. 588, pp. 119–131). Springer New York. https://doi.org/10.1007/978-0-387-34817-9_11
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