Abstract
To determine if the indolic nitrogen atom is required for the binding of N1-benzyltryptamines at h5-HT6 serotonin receptors, several isotryptamines and indene analogs were examined. The affinity of 3-benzyl-N1-(N,N-dimethylaminoethyl)indole (5, Ki = 32 nM) and 1-benzyl-3-(N,N-dimethylaminoethyl)indene (11, Ki = 3 nM) indicates that the indolic nitrogen atom is not essential for binding. © 2005 Elsevier Ltd. All rights reserved.
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Kolanos, R., Siripurapu, U., Pullagurla, M., Riaz, M., Setola, V., Roth, B. L., … Glennon, R. A. (2005). Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorganic and Medicinal Chemistry Letters, 15(8), 1987–1991. https://doi.org/10.1016/j.bmcl.2005.02.070
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