Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

  • Ranjith R
  • Devika P
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Abstract

Objective: The aim of this study was to evaluate correlation between plasma homocysteine and coronary artery disease (CAD) in Indian patients. Methods: This study included 150 patients, 100 subjects in study group with angiographically diagnosed CAD and 50 subjects in control group with a normal coronary angiogram. In the study group, patients were divided into three subgroups viz.: CAD only, CAD with hypertension and CAD with type 2 diabetes mellitus. Plasma homocysteine, lipid profile and other risk factors were compared. Results: Mean homocysteine levels in study group (38.34 ± 15.25 μmol/L) were significantly higher (p < 0.01) than control group (9.41 ± 4.22 μmol/L). No association was found between homocysteine level and conventional risk factors. Furthermore, no significant correlation was found between plasma homocysteine and lipid components in different groups of patients. Conclusion: The study demonstrated that increased levels of homocysteine are independently related to CAD. However, further studies involving a larger sample size will be required to substantiate the findings of the current study.

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Ranjith, R., & Devika, P. (2017). Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients. World Journal of Cardiovascular Diseases, 07(12), 477–485. https://doi.org/10.4236/wjcd.2017.712047

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