To define a potential role for the angiotensin system in Crohn's colitis, the colonic mucosal levels of angiotensin I and II were measured in endoscopic biopsy samples from patients with active Crohn's colitis (n = 20), ulcerative colitis (n = 13), other forms of colitis (n = 3), and normal controls (n = 17). Colonic mucosal levels of angiotensin I and II were greater in patients with Crohn's colitis than in normal subjects (p < 0.001 and p < 0.001, respectively). Mucosal levels of angiotensin I and II were also higher in Crohn's colitis than in ulcerative colitis (p < 0.001 and p < 0.001, respectively), and levels of angiotensin II were higher in Crohn's than in other forms of colitis (p = 0.014). Mucosal levels of angiotensin I and II correlated well with the degree of macroscopic inflammation in Crohn's colitis (r = 0.86, p < 0.001 and r = 0.68, p < 0.001, respectively). Mucosal levels of angiotensin I correlated fairly well with the Crohn's Disease Activity Index (r = 0.46, p < 0.05) while angiotensin II levels correlated poorly. These studies suggest that angiotensin I and II may have a role in the inflammation associated with Crohn's colitis. © 1990.
Jaszewski, R., Tolia, V., Ehrinpreis, M. N., Bodzin, J. H., Peleman, R. R., Korlipara, R., & Weinstock, J. V. (1990). Increased colonic mucosal angiotensin I and II concentrations in Crohn’s colitis. Gastroenterology, 98(6), 1543–1548. https://doi.org/10.1016/0016-5085(90)91088-N