Juvenile myoclonic epilepsy and human leukocyte antigens

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The idiopathic generalized epilepsies (IGE) occur with a high aggregation within families. Juvenile myoclonic epilepsy (JME) is recognized as a commonly occurring form of idiopathic generalized epilepsy. A possible association between JME and HLA antigens was investigated by serological typing of human leukocyte antigens (HLA) class I antigens and by DNA oligotyping of class II antigens. Twenty-four patients and 129 controls, all Caucasians of Scandinavian descent, were tested. Uncorrected there was a significant positive association (Relative risk (RR) = 8.07) to B17 and a significant negative association (RR = 0.13) to B8 as well as DRB1*3. The negative association to DQ alleles DQAI*0501 and DQB1*0201, which are in strong linkage disequilibrium with the alleles B8 and DRB1*3, was weaker and not significant, thus giving no clue as to a primary HLA-DQ association of JME. © 1995 British Epilepsy Association.




Moen, T., Brodtkorb, E., Michler, R. P., & Holst, A. (1995). Juvenile myoclonic epilepsy and human leukocyte antigens. Seizure: European Journal of Epilepsy, 4(2), 119–122. https://doi.org/10.1016/S1059-1311(95)80090-5

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