Seguridad de la ivermectina: Toxicidad y reacciones adversas en diversas especies de mamíferos

Abstract

The antiparasitic drug Ivermectin is frequently used in veterinary medicine, due to its broad spectrum of activity (both against endoand ectoparasites, high efficacy and wide margin of safety. However, its administration can give rise to toxic effects. Most of them come from the overdosage of the compound, although, at therapeutic doses, it also has been described an increased susceptibility to Ivermectin toxicosis in some breeds and subpopulations of animals, as well as severe anaphylactic reactions due to the sudden massive release of parasite toxins.