Design and synthesis of naphthol derivative

Abstract

In this study a naphthalene derivative was synthetized using several strategies; in first stage a steroid derivative (3) was development by the reaction between androsterone and ethylenediamine using boric acid as catalyst. In the second stage compound 3 was used in the three-component system (β-naphthol, benzaldehyde and compound 3) for the synthesis of 17-(2-[[(2-hydroxy-naphtalen-1-yl)-phenyl-methyl] amino]ethylamino)-10,13- dimethyl-2,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a] -phenanthren-3-ol (6). In addition, a second method was used to form 6. In this technique 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol was made reacting with androsterone to form 6 using boric acid as catalyst. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods. © 2013 Asian Journal of Chemistry.