Discovery of a novel (+)- γ-lactamase from Bradyrhizobium japonicum USDA 6 by rational genome mining

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Abstract

A novel (+)-γ-lactamase used for the resolution of racemic γ-lactam from Bradyrhizobium japonicum USDA 6 was found as a result of sequence-structure guided genome mining. It consists of 409 amino acids, only 49% of which are identical to the amino acid sequences of the known (+)-γ-lactamase from Sulfolobus solfataricus. This is only the third (+)-γ-lactamase gene to be reported. © 2012, American Society for Microbiology.

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Zhu, S., Gong, C., Song, D., Gao, S., & Zheng, G. (2012). Discovery of a novel (+)- γ-lactamase from Bradyrhizobium japonicum USDA 6 by rational genome mining. Applied and Environmental Microbiology, 78(20), 7492–7495. https://doi.org/10.1128/AEM.01398-12

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