Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection

Abstract

Background: Myocardial ischemia and cardioprotection induce signal networks mediated by post-translational modification. Results: Phosphorylation sites altered by ischemia and/or cardioprotection were influenced by inhibition of lysine acetylation consistent with cross-talk. Conclusion: Lysine acetylation induces proximal dephosphorylation in a kinase motif by salt bridge inhibition. Significance: Cross-talk is likely to be an important aspect of signaling during ischemia and cardioprotection.