Procesos celulares modificados en Aedes aegypti infectados con Wolbachia y la susceptibilidad al virus dengue

Abstract

Objective. To analyze the differential expression of proteins of Ae. aegypti infected with Wolbachia and its association with the viral cycle of dengue virus (DENV). Materials and methods. We review a database of proteins from Ae. aegypti infected and uninfected with Wolbachia and we reviewed published articles in peer-reviewed journals that talk about participation in the protein and viral cycle of DENV. Results. We found proteins that expressed changes in Wolbachia infection, some increased and others decreased, which participate in the processes of entry, replication, and exit of DENV. Conclusions. There are changes in protein expression of Wolbachia-infected cells, which are necessary for the DENV replication cycle, explaining why some Wolbachia-infected mosquitoes are refractory to DENV infection