The beta subunit controls the gating and dihydropyridine sensitivity of the skeletal muscle Ca2+ channel

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Abstract

The skeletal muscle (SKM) L-type Ca2+ channel is composed of a central subunit designated alpha 1, which contains the pore and the dihydropyridine (DHP) binding domains and three associated subunits, alpha 2/delta, beta, and gamma, which influence the activity of the SKM alpha 1. Coexpression of SKM alpha 1 and SKM beta in stably transfected mouse L cells results in a dramatic increase in DHP binding accompanied by fast gated Ba2+ currents. We report here that this "SKM alpha 1 beta-related phenotype" can be converted upon intracellular trypsin treatment into a slowly inactivating, DHP sensitive "SKM alpha 1 phenotype." These observations indicate that current amplitude, fast inactivation, and DHP sensitivity are modulated by an interaction of SKM alpha 1 and SKM beta on the internal side of the membrane. © 1992, The Biophysical Society. All rights reserved.

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Lory, P., Varadi, G., & Schwartz, A. (1992). The beta subunit controls the gating and dihydropyridine sensitivity of the skeletal muscle Ca2+ channel. Biophysical Journal, 63(5), 1421–1424. https://doi.org/10.1016/S0006-3495(92)81705-8

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