Inside Back Cover: Direct Asymmetric Michael Reaction of α,β‐Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts (Angew. Chem. Int. Ed. 7/2018)

Abstract

Two pyrrolidine catalysts together promote the asymmetric Michael addition of cyclic ketones to α,β-unsaturated aldehydes, as described by Y. Hayashi and N. Umekubo in their Communication (DOI: 10.1002/anie.201710085). Although several iminium and enamine species exist in the reaction mixture, only the two of them are active catalysts in this reaction. This scenario is illustrated by the two foxes, while the product is shown on the summit of Mt. Fuji.