Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4+CD25+ regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3+ Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3 + Treg cells. © 2013 Cathleen Petzold et al.
Petzold, C., Riewaldt, J., Watts, D., Sparwasser, T., Schallenberg, S., & Kretschmer, K. (2013). Foxp3+ regulatory T cells in mouse models of type 1 diabetes. Journal of Diabetes Research. https://doi.org/10.1155/2013/940710