N-(2-Ferrocene-ethyl)maleimide: A new electroactive sulphydryl-specific reagent for cysteine-containing peptides and proteins

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Abstract

We report the synthesis and application of a specific electroactive label, N-(2-ferrocene-ethyl)maleimide, which provides new redox properties to organic compounds and proteins possessing sulphydryl groups. Its reaction conditions with the cysteine-containing peptide, glutathione, and a terminal monooxygenase enzyme, cytochrome P450(cam) are presented. The labelled peptide and enzyme acquired reversible electrochemical properties due to the attached ferrocene moiety.

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Di Gleria, K., Hill, H. A. O., & Wong, L. L. (1996). N-(2-Ferrocene-ethyl)maleimide: A new electroactive sulphydryl-specific reagent for cysteine-containing peptides and proteins. FEBS Letters, 390(2), 142–144. https://doi.org/10.1016/0014-5793(96)00648-5

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