The design, synthesis, and characterization of resveratrol derivatives modified by different γ-Aminobutyric acid esters

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Abstract

A novel series of resveratrol modified by γ-Aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, which correlated well with molecular transport through membranes and, therefore, enabled prediction of transport properties of drugs.

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Tian, B. R., Liu, J. Y., Ge, H. R., Wang, Z. Z., Huang, S. Y., Wang, Y. Y., … Zhang, R. X. (2019). The design, synthesis, and characterization of resveratrol derivatives modified by different γ-Aminobutyric acid esters. Journal of Chemistry, 2019. https://doi.org/10.1155/2019/3050486

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