Effect of Different Potencies of Nanomedicine Aconitum Napelles on Its Spectral and Antibacterial Properties

Abstract

The homeopathic drug Aconitum napelles, a drug of aconitum species, is used extensively for its anti-inflammatory and vasodialatory action. We report here our study on how the increase in the potency of the drug affects its spectral characteristics, namely UV-Vis spectra, Fourier Transform Infrared Radiation (FTIR) spectra, Raman spectra and Field Emission Scanning Electron Microscopy (FESEM). The absorption peaks of the UV-Vis and FTIR spectra indicate definite signature of decrease in the size of the drug aggregates with increase in potency of the drug. This is confirmed in the FESEM study. Raman spectra indicate that there is no associated change in chemical structure due to potentization. Using Staphylococcus aureus, a gram positive bacteria and Escherichia coli, gram negative bacteria, we have also shown here how the change in potency of the drug affects its antibacterial property. A possible explanation of these effects has been put forwarded at the molecular level.