Biochemistry of the endogenous ligands of cannabinoid receptors

95Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.
Get full text

Abstract

In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an 'endogenous cannabinoid regulatory system' exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was the first of a series of long-chain fatty acid derivatives, including two other polyunsaturated N- acylethanolamines and 2-arachidonoyl-glycerol, found to exert cannabimimetic properties in either central or peripheral tissues. Here we review the current knowledge on the biochemical bases of the formation and inactivation of endogenous cannabinoid ligands as well as of their interaction with cannabinoid receptor subtypes.

Cite

CITATION STYLE

APA

Di Marzo, V., & Deutsch, D. G. (1998). Biochemistry of the endogenous ligands of cannabinoid receptors. Neurobiology of Disease, 5(6), 386–404. https://doi.org/10.1006/nbdi.1998.0214

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free