Biosynthesis of Rishirilide B

  • Schwarzer P
  • Wunsch-Palasis J
  • Bechthold A
  • et al.
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Abstract

Rishirilide B was isolated from Streptomyces rishiriensis and Streptomyces bottropensis on the basis of its inhibitory activity towards alpha-2-macroglobulin. The biosynthesis of rishirilide B was investigated by feeding experiments with different 13C labelled precursors using the heterologous host Streptomyces albus J1074::cos4 containing a cosmid encoding of the gene cluster responsible for rishirilide B production. NMR spectroscopic analysis of labelled compounds demonstrate that the tricyclic backbone of rishirilide B is a polyketide synthesized from nine acetate units. One of the acetate units is decarboxylated to give a methyl group. The origin of the starter unit was determined to be isobutyrate.

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Schwarzer, P., Wunsch-Palasis, J., Bechthold, A., & Paululat, T. (2018). Biosynthesis of Rishirilide B. Antibiotics, 7(1), 20. https://doi.org/10.3390/antibiotics7010020

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