The birth weight lowering c-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

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Abstract

The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.

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Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stančáková, A., Kuusisto, J., … Hansen, T. (2011). The birth weight lowering c-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge. PLoS ONE, 6(11). https://doi.org/10.1371/journal.pone.0027096

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