Delevoye et al. define the function of BLOC-1, mutated in neurological and pigmentary disorders. BLOC-1 forms recycling endosomes by orchestrating elongation and scission of tubules from sorting endosomes. By cooperating with microtubule (KIF13A) and actin (Annexin A2) components, BLOC-1 functions in cargo recycling and melanosome biogenesis.
Delevoye, C., Heiligenstein, X., Ripoll, L., Gilles-Marsens, F., Dennis, M. K., Linares, R. A., … Raposo, G. (2016). BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes. Current Biology, 26(1), 1–13. https://doi.org/10.1016/j.cub.2015.11.020