Body mass index and retinopathy in type 1 diabetic patients

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Abstract

Aim . To investigate whether body mass index (BMI) independently or in correlation with other risk factors is associated with diabetic retinopathy (DR) progression. Methods. The study included 176 patients with type 1 diabetes divided into three groups according to DR status: group 1 (no retinopathy; n=86 ), group 2 (mild/moderate nonproliferative DR; n=33 ), and group 3 (severe/very severe NPDR or proliferative DR; n=57 ). Results . A significant deterioration of HbA 1 c, an increase in total cholesterol, systolic, diastolic blood pressure, and diabetic nephropathy with the progression of retinopathy were found. DR progression was correlated with diabetes duration, HbA 1 c, hypertension, total cholesterol, and the presence of nephropathy. In patients without nephropathy, statistical analyses showed that progression of retinopathy increased significantly with higher BMI (gr. 1: 24.03 ± 3.52, gr. 2: 25.36 ± 3.44, gr. 3: 26.93 ± 3.24; P<0.01 ). A positive correlation between BMI and a significant deterioration of HbA 1 c, an increase in cholesterol, triglycerides, and hypertension was observed. Conclusion . BMI in correlation with HbA 1 c, cholesterol, and hypertension appears to be associated with the progression of DR in type 1 diabetic patients without nephropathy. However, additional studies are required to investigate the pathogenic role of obesity and weight loss in retinal diabetic complications particularly relating to nephropathy.

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APA

Kaštelan, S., Salopek Rabatić, J., Tomić, M., Gverović Antunica, A., Ljubić, S., Kaštelan, H., … Orešković, D. (2014). Body mass index and retinopathy in type 1 diabetic patients. International Journal of Endocrinology, 2014. https://doi.org/10.1155/2014/387919

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