Bone strength and arterial stiffness impact on cardiovascular mortality in a general population

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Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852±0.1432 g/cm2, 0.934±0.1546 g/cm2, and 9.209±1.9815 m/s. In multiple regression analysis we found BMD FN (βst =-6.0094, p<0.0001), hypertension (βst = 1.7340, p<0.0091), and diabetes (βst=0.4595, p<0.0046). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN (b=-2.4129, p=0.015) and PWV (b=0.2606, p=0.0318). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm2, and BMD LS = 0.992 g/cm2. The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP.




Avramovski, P., Avramovska, M., & Sikole, A. (2016). Bone strength and arterial stiffness impact on cardiovascular mortality in a general population. Journal of Osteoporosis, 2016.

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