Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode

20Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Alphaviruses are a family of positive-strand RNA viruses that circulate on all continents between mosquito vectors and vertebrate hosts. Despite a significant public health threat, their biology is not sufficiently investigated, and the mechanisms of alphavirus replication and virus-host interaction are insufficiently understood. In this study, we have applied a variety of experimental systems to further understand the mechanism by which infected cells detect replicating alphaviruses. Our new data strongly suggest that activation of the antiviral response by alphavirus-infected cells is determined by the integrity of viral genes encoding proteins with nuclear functions, and by the presence of two cellular pattern recognition receptors (PRRs), RIG-I and MDA5. No type I IFN response is induced in their absence. The presence of either of these PRRs is sufficient for detecting virus replication. However, type I IFN activation in response to pathogenic alphaviruses depends on the basal levels of RIG-I or MDA5.

Cite

CITATION STYLE

APA

Akhrymuk, I., Frolov, I., & Frolova, E. I. (2016). Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode. Virology, 487, 230–241. https://doi.org/10.1016/j.virol.2015.09.023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free