Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events

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Abstract

The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other. © 1988.

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Adam-Vizi, V., Rosener, S., Aktories, K., & Knight, D. E. (1988). Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events. FEBS Letters, 238(2), 277–280. https://doi.org/10.1016/0014-5793(88)80496-4

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