Brain activation differences in schizophrenia during context-dependent processing of saccade tasks

4Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Background: Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades). Results: Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group. Conclusions: Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.

Cite

CITATION STYLE

APA

Rodrigue, A. L., Austin, B. P., Dyckman, K. A., & McDowell, J. E. (2016). Brain activation differences in schizophrenia during context-dependent processing of saccade tasks. Behavioral and Brain Functions, 12(1). https://doi.org/10.1186/s12993-016-0103-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free