Brain Metastases in gastrointestinal cancers: Is there a role for surgery?

8Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

© 2014 by the authors; licensee MDPI, Basel, Switzerland. About 10% of all cancer patients will develop brain metastases during advanced disease progression. Interestingly, the vast majority of brain metastases occur in only three types of cancer: Melanoma, lung and breast cancer. In this review, we focus on summarizing the prognosis and impact of surgical resection of brain metastases originating from gastrointestinal cancers such as esophageal, gastric, pancreatic and colorectal cancer. The incidence of brain metastases is <1% in pancreatic and gastric cancer and <4% in esophageal and colorectal cancer. Overall, prognosis of these patients is very poor with a median survival in the range of only months. Interestingly, a substantial number of patients who had received surgical resection of brain metastases showed prolonged survival. However, it should be taken into account that all these studies were not randomized and it is likely that patients selected for surgical treatment presented with other important prognostic factors such as solitary brain metastases and exclusion of extra-cranial disease. Nevertheless, other reports have demonstrated long-term survival of patients upon resection of brain metastases originating from gastrointestinal cancers. Thus, it appears to be justified to consider aggressive surgical approaches for these patients.

Cite

CITATION STYLE

APA

Lemke, J., Scheele, J., Kapapa, T., von Karstedt, S., Wirtz, C. R., Henne-Bruns, D., & Kornmann, M. (2014, September 22). Brain Metastases in gastrointestinal cancers: Is there a role for surgery? International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms150916816

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free