BRCA1 forks over new roles in DNA-damage response- before and beyond the breaks

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Abstract

In this issue, Pathania et al. (2011) report the involvement of BRCA1 in ultraviolet (UV)-damage response at stalled replication forks, which extends the function of BRCA1 beyond its established role in the repair of DNA- double-strand breaks (DSBs), raising the complexity of how this tumor suppressor maintains genomic stability. © 2011 Elsevier Inc.

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Li, L. (2011, October 21). BRCA1 forks over new roles in DNA-damage response- before and beyond the breaks. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.10.003

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