Brucella sp. bind to sialic acid residues on human and animal red blood cells

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Abstract

We report that Brucella abortus and Brucella melitensis agglutinate human (A+ and B+), hamster and rabbit erythrocytes, a heretofore undescribed feature in this genus. This activity was associated with a 29-kDa surface protein (SP29) that bound selectively to these erythrocytes and this binding was inhibited by rabbit anti-SP29 antibodies. Hemagglutination was inhibited by pretreatment of erythrocytes with neuraminidase and by preincubation of B. abortus with chondroitin sulfate, N-acetylneuraminic acid and N-acetylneuramin-lactose. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

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Rocha-Gracia, R. D. C., Castañeda-Roldán, E. I., Giono-Cerezo, S., & Girón, J. A. (2002). Brucella sp. bind to sialic acid residues on human and animal red blood cells. FEMS Microbiology Letters, 213(2), 219–224. https://doi.org/10.1016/S0378-1097(02)00817-0

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