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Abstract

The aim of this study was to estimate the budget impact of collagenase Clostridium histolyticum (CCH) vs. fasciectomy (FSC) surgery for the treatment of Dupuytren's disease (DD) in Spain. A cost minimization analysis was adopted (effectiveness was assumed to be equivalent for both techniques). DD related costs were considered. CCH costs (including drug, administration and visits) were obtained from clinical trials and a real-life study. FSC costs (including type of admission, visits, operating room, re-admissions, tests, drugs and rehabilitation costs) were collected through a retrospective, observational, local study. Unit costs were obtained from local database systems (e-SALUD and BOT). Results were presented from the NHS perspective for the next 3. years. We assumed that there were 5100 fasciectomies per year (with a 5% annual increase) and that 20%, 30% and 40% of them will annually utilize CCH. In addition, a 10%, 15% and 20% of untreated diagnosed patients were expected to receive CCH. All the data were validated through an expert panel. A sensitivity analysis was performed with the main variables. The average FSC cost was € 2250 (72% inpatients), € 1703 for outpatients and € 2467 for inpatients. The average CCH cost was € 1220 (1.5 vial/injection and four visits) and could drop to € 898 (1.1 vial/injections and three visits). The accumulated 3. years budget impact analysis (BIA) was 45,971. € (K€ -2993. 11Negative numbers refer to savings.; 3870). According to this study, the inclusion of the CCH should produce a 3-year cumulative budgetary impact of € 45,971 (K€ -2993; 3870) for the NHS. © 2013 Elsevier Masson SAS.

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APA

M., D. S.-C., M., C., M., D. C., & J.M., A. (2013). Budget impact analysis in Spanish patients with Dupuytren’s contracture: Fasciectomy vs. collagenase Clostridium histolyticum. Chirurgie de La Main, 32(2), 68–73. https://doi.org/10.1016/j.main.2013.02.012 LK  - http://limo.libis.be/resolver?&sid=EMBASE&issn=12973203&id=doi:10.1016%2Fj.main.2013.02.012&atitle=Budget+impact+analysis+in+Spanish+patients+with+Dupuytren%27s+contracture%3A+Fasciectomy+vs.+collagenase+Clostridium+histolyticum&stitle=Chir.+Main&title=Chirurgie+de+la+Main&volume=32&issue=2&spage=68&epage=73&aulast=De+Salas-Cansado&aufirst=M.&auinit=M.&aufull=De+Salas-Cansado+M.&coden=CMAIF&isbn=&pages=68-73&date=2013&auinit1=M&auinitm=

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