New cembranolides from the Dongsha Atoll soft coral Lobophytum durum

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Abstract

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M-Q (1-5). The structures of compounds 1-5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL. © 2011 by the authors; licensee MDPI.

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Cheng, S. Y., Chen, P. W., Chen, H. P., Wang, S. K., & Duh, C. Y. (2011). New cembranolides from the Dongsha Atoll soft coral Lobophytum durum. Marine Drugs, 9(8), 1307–1318. https://doi.org/10.3390/md9081307

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