Corrigendum: Signaling Pathways Regulating Thermogenesis (Front. Endocrinol., (2021), 12, 595020, 10.3389/fendo.2021.595020)

Abstract

In the original article, there were errors in Figures 1 and 2. In Figure 1, IRF4 had to be removed and the order of the transcription factors had to be reorganized during this correction. In Figure 2, SMAD2 needs to be removed. The corrected Figures 1 and 2 are below. In the original article, there were errors in the text. IRF4 needed to be replaced with PGC1a as a downstream target of p38. PGC1a and DIO needed to be removed as downstream targets of CREB, due to insufficient research. A correction has been made to the section b3-Adrenergic Signaling, the second paragraph: “p38, a MAP kinase, phosphorylates multiple transcription factors/coregulators, including ATF2 and PGC1a, both of which promote UCP1 transcription (22). In addition, we recently found that ZC3H10, previously known to bind RNA, is phosphorylated by p38 upon cold, activating the thermogenic gene program in adipocytes (17). Specifically, ZC3H10 binds a distal upstream region of the UCP1 promoter for transcriptional activation. ZC3H10 also activates NRF1 and TFAM, which facilitate mitochondrial biogenesis to increase thermogenic capacity of adipocytes. Thus, transgenic mice overexpressing ZC3H10 exhibited increased oxygen consumption, higher BAT temperature and reduced body weight while ZC3H10 knockout mice displayed decreased oxygen consumption, lower BAT temperature and increased body weight. PGC1a, a downstream target of p38, serves as co-activator for PPARg and NRF1 to induce expression of UCP1 and TFAM, respectively (27, 28). CREB was also shown to bind to the proximal promoter of UCP1 to potentially activate the transcription.” The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.