Effect of the Ethanol Extract of Mimosa Leaves on the Blood Glucose, Malondialdehyde, and Histopathological Characteristics of Wistar Rats

Abstract

BACKGROUND: Hyperglycemia, a condition characterized by high blood glucose levels, is one of the hallmarks of type 2 diabetes mellitus. AIM: This study aimed to (1) determine if the ethanol extract of Mimosa leaves could lower blood glucose levels in Wistar rats with hyperglycemia and (2) identify the components of active compounds with antihyperglycemic properties. METHODS: In the blood glucose level reduction test, Wistar rats were used as an animal model of diabetes induced by streptozotocin. Blood glucose levels were measured using a glucometer, and active compounds were identified through Liquid Chromatography with tandem mass spectrometry (LCMS/MS). RESULTS: Results showed that the ethanol extract of Mimosa pudica leaves might significantly lower the blood glucose, and malondialdehyde levels of rats with hyperglycemia at 150 mg/kg BB (p < 0.05). LCMS/MS analysis revealed that the ethanol extract of Mimosa leaves likely contained seven compounds that could decrease blood glucose and malondialdehyde levels: DL-valine, indoline, 2-quinolinol, trans-anrthole, luteolin, apigenin, linoliamide, and luteolinin. CONCLUSION: Histophatological determination with HE staining for pancreas.