Vinigrol, a novel antihypertensive and platelet aggregation inhibitory agent produced by a fungus, virgaria nigra. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

Abstract

Vinigrol, produced by a fungal strain identified as Virgaria nigra, was extracted from the cultured mycelium, purified by solvent extraction followed by chromatography on silica gel and then isolated as crystals (C20H34O3, mp 108°C). Vinigrol decreased arterial blood pressure of anesthetized normotensive rats dose-dependently when administered intravenously. Vinigrol inhibited platelet activating factor and epinephrine induced platelet aggregation. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.