Protecting-group-free route to hydroxylated pyrrolidine and piperidine derivatives through Cu(I)-catalyzed intramolecular hydroamination of alkenes

Abstract

An efficient approach to hydroxylated pyrrolidine and piperidine derivatives through the intramolecular hydroamination catalyzed by a Cu(I)-Xantphos system is described. The transformation allows for the short synthesis of N-alkylated aza-sugars without a protection-deprotection event of the hydroxy groups. © Georg Thieme Verlag Stuttgart New York.